Bacillus anthracis Protéine

N° du produit ABIN935200

Protéine Recombinant Bacillus anthracis exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Bacillus anthracis Protéine (ABIN935200)

Antigène: Bacillus anthracis

Type de proteíne: Recombinant

Origine: Bacillus anthracis

Source: Escherichia coli (E. coli)

Détail du produit

Attributs du produit: Purified recombinant Bacillus Anthracis (Anthrax) protein (Protective Antigen)

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from 10 mM BIS-Tris propane, pH 8.5, with 1.25 % trehalose.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C

Stockage commentaire: Store at 4 °C.

Détail du antigène

Antigène: Bacillus anthracis

Classe de substances: Bacteria

Sujet: PA63 is the carboxyl-terminal 63- kDa fragment obtained by the proteolytic cleavage of the receptor-bound protective antigen (PA), one of the three proteins that comprise anthrax toxin. Unlike native PA, PA 63 oligomerizes to form a ring-shaped heptamer that binds up to three copies of EF and/or LF competitively and with high affinity (kDa ~1 nM). Whereas native PA persists on the cell surface, the heptamer is endocytosed, presumably because oligomerization aggregates anthrax toxin receptor. The endocytosed toxic complexes are trafficked to endosomal compartments where the low pH causes the PA63 heptamer to insert into the membrane and form a water-filled channel.
Alternative Names: Bacillus Anthracis Protein, Bacillus anthracis Protective Nicked Antigen, Anthrax Protein, Recombinant B Anthracis

Poids moléculaire: 63 kDa